RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis
نویسندگان
چکیده
منابع مشابه
Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma.
The Ras/Raf/MEK/ERK signalling cascade is frequently deregulated in tumourigenic diseases and known to be involved in proliferation and transformation of cells. Also in hepatocellular carcinoma (HCC) increased ERK levels are observed and known to correlate with tumour progression, but the underlying molecular mechanism are unknown. We analyzed expression of Raf-1 kinase inhibitory protein (RKIP...
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Raf kinase inhibitory protein (RKIP; also known as phosphatidylethanolamine-binding protein or PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. Here, we show that RKIP inhibits MAPK by regulating Raf-1 activation; specifically, RKIP acts subsequent to Raf-1 membrane recruitment, prevents association of Raf-1 and p21-activated kinase (PAK), and blocks...
متن کاملRaf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β.
Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor κB signaling that represses tumor invasion and metastasis. Glycogen synthase kinase-3β (GSK3β) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show that RKIP binds GSK3 proteins and maintains GSK3β protein levels...
متن کاملMolecular and Cellular Pathobiology Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3b
Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor kB signaling that represses tumor invasion andmetastasis.Glycogen synthase kinase-3b (GSK3b) suppresses tumorprogression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show thatRKIPbindsGSK3proteins andmaintainsGSK3bprotein levels and its a...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20225756